首页|Distinguishing Rectal Cancer from Colon Cancer Based on the Support Vector Machine Method and RNA-sequencing Data

Distinguishing Rectal Cancer from Colon Cancer Based on the Support Vector Machine Method and RNA-sequencing Data

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Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide.Several studies have indicated that rectal cancer is significantly different from colon cancer in terms of treatment,prognosis,and metastasis.Recently,the differential mRNA expression of colon cancer and rectal cancer has received a great deal of attention.The current study aimed to identify significant differences between colon cancer and rectal cancer based on RNA sequencing (RNA-seq) data via support vector machines (SVM).Here,393 CRC samples from the The Cancer Genome Atlas (TCGA) database were investigated,including 298 patients with colon cancer and 95 with rectal cancer.Following the random forest (RF) analysis of the mRNA expression data,96 genes such as HOXB13,PRAC,and BCLAF1 were identified and utilized to build the SVM classification model with the Leave-One-Out Cross-validation (LOOCV) algorithm.In the training (n=196) and the validation cohorts (n=197),the accuracy (82.1％ and 82.2 ％,respectively) and the AUC (0.87 and 0.91,respectively) indicated that the established optimal SVM classification model distinguished colon cancer from rectal cancer reasonably.However,additional experiments are required to validate the predicted gene expression levels and functions.

colon cancerrectal cancersupport vector machineclassificationgene selection

Yan ZHANG、Yuan WU、Zi-ying GONG、Hai-dan YE、Xiao-kai ZHAO、Jie-yi LI、Xiao-mei ZHANG、Sheng LI、Wei ZHU、Mei WANG、Ge-yu LIANG、Yun LIU、Xin GUAN、Dao-yun ZHANG、Bo SHEN

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Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, China

Shanghai Yunying Medical Technology Co., Ltd., Shanghai 201612, China

Jiaxing Yunying Medical Inspection Co., Ltd., Jiaxing 314000, China

School of Medicine, Jiangsu University, Zhenjiang 212013, China

School of Public Health, Southeast University, Nanjing 211189, China

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Six Talent Peaks Project in Jiangsu ProvinceBeijing Medical Award FoundationFoundation of Social Development Project of the Science and Technology Department of Jiangsu ProvinceSocial Development Key Research and Development Plan of Jiangsu ProvinceFoundation of Nanjing Medical University

2014-wsw-017YJHYXKYJJ-432BE2015719BE20176942017NJMUZD140

2021

10.1007/s11596-021-2356-8

当代医学科学(英文)
同济医科大学

当代医学科学(英文)

SCI
ISSN：2096-5230
年,卷(期)：2021.41(2)
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