Hot spring water has the characteristics of deep circulation,fast-rising speed,and little human influence,and its chemical and isotopic composition carries the informa-tion of deep environment changes,it is becoming an important content of earthquake pre-cursor monitoring.Based on domestic and foreign relevant literature,this article emphasi-zes the superiority of hot spring water monitoring in earthquake prediction in areas with harsh natural conditions and sparse populations,such as the Qianghai-Tibet Plateau and Xinjiang,where strong earthquakes are active.It summarizes the precursory response of the chemistry and isotope of hot spring water to earthquakes and the mechanism of abnor-mal response and proposes that identifying the sources of hot spring water and solute,the hydrogeochemical processes,and the seismic precursory signals during the process of earthquake breeding and occurrence are the key questions to answer how hot spring water responds to earthquakes.It is recognized that seismic prediction based on big data analysis and machine learning can play an important role in the analysis of the monitoring data of hot spring water.In addition,it is expected that the eastern margin of the Qinghai-Tibet Plateau could be the best research area to further study the mechanism of hydrochemical response to earthquakes.The purpose of this paper is to promote the development of chemical and isotopic monitoring of hot spring water for earthquake prediction and to im-prove the ability of earthquake prevention and disaster reduction.