Type Ⅵ secretion system(T6SS)as a protein secretion system exists within varieties of gram-negative bacteria,and plays important roles in virulent factors release,biofilm formation,iron ion uptake,vesicular transport and environmental pressure adaptability,which is crucial for the pathogenesis of aquatic bacterial pathogens such as Vibrio parahaemolyticus,V.alginolyticus,V.harveyi,Aeromonas hydrophila,and Edwardsiella tarda.However,the reports regarding the components and functions of T6SS from aquatic pathogenic bacteria are still rare.The lat-est research progress on biological functions,regulatory mechanisms of T6SS,as well as the biological roles,evolu-tionary relationships of the key regulator of T6SS-hemolysin coregulatory protein(Hcp)is summarized from several aquatic bacterial pathogens.Several future key directions are proposed including new biofunctional discoveries of T6SS,correlation between T6SS activity and environmental factors,the regulation between T6SS and virulence-re-lated metabolism.This review will help researchers better understand the roles of aquatic animal pathogens T6SS and provide new ideas for further research on pathogenic mechanism and control of bacterial diseases in aquacul-ture.
关键词
Ⅵ型分泌系统/水生动物病原菌/溶血素共调节蛋白/系统进化树/功能位点
Key words
type Ⅵ secretory system/aquatic animal pathogen/hemolysin coregulatory protein/phylogenetic tree/functional site
维普
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