Mechanisms and intervention strategies of tumor chemoresistance
Despite the continuous improvements of cancer treatment methods,chemotherapy is still the main approach of cancer treatment.During chemotherapy,patients easily develop tolerance to chemotherapeutics through endogenous or acquired mechanisms,which severely limits the therapeutic effect of chemotherapy and greatly affects the prognosis of patients.The mechanisms by which chemoresistance arises are diverse,and strategies to specifically target chemo-resistant cancer cells remain limited in clinical practice.Therefore,it is crucial to fully understand and grasp the mechanisms of tumor chemoresistance in order to formulate better chemotherapy regimens,take targeted interventions,and improve the survival rate of patients.This article summarizes the research progress on the related mechanisms and intervention strategies of tumor chemoresistance.
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