Relationship between plasma homocysteine and severity of varicocele
Objective To investigate the correlation between plasma homocysteine and the severity of varicocele (VC) in order to study the pathogenesis of VC.Methods A total of 100 patients aged 16-46 with VC were selected, who visited the Department of Andrology and Sexual Medicine at the Second Hospital of Dalian Medical University from January 2022 to January 2024.According to the severity of VC, all patients were divided into 3 groups: group A with grade Ⅰ VC (34 cases), group B with grade Ⅱ VC (14 cases), and group C with grade Ⅲ VC (52 cases).Data on patients' age, neutrophils, lymphocytes, monocytes, eosinophils, platelets, platelets (MPV), mean red blood cell volume (MCV), platelet distribution width (PDW), plasma Hcy, prolactin, follicle stimulating hormone, luteinizing hormone, testosterone, estradiol, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), eosinophil to lymphocyte ratio (ELR) and the maximum inner diameter of the spermatic vein were collected.The differences in clinical indicators between the groups were compared.Univariate and multivariate linear regression was used to analyze the factors related to the severity of VC.Results The Hcy levels in patients with grade Ⅰ, Ⅱ, and Ⅲ VC were 10.01 (9.01, 12.18)µmol/L, 11.16 (10.27, 12.62)µmol/L, and 12.56 (9.90, 14.62)µmol/L, respectively.The differences among the three groups were statistically significant (H=5.85, P=0.048).Other indicators were not statistically significant when compared among the three groups (P>0.05).Additionally, multivariate regre-ssion analysis revealed that Hcy was a factor associated with the severity of VC (t=2.27, P=0.026).Conclusion Hcy is correlated with the severity of VC and has certain clinical value in assessing the severity of VC.
homocysteinevaricocelemaximum inner diameter of the spermatic vein
万方数据
维普
