The development of anti-tumor drugs has long faced challenges such as lengthy development cycles, significant variability in drug efficacy in vivo, and differences in effectiveness among individuals.Patient-derived tumor organoids (PDTO) are three-dimensional cultures of tumor cells that can be expanded for a long time, simulating the characteristics of in vivo tumors and tumor cell heterogeneity.In recent years, PDTOs have shown great potential in the field of high-throughput drug screening and personalized medicine.This article reviews the construction of PDTO models and their application in anti-tumor drug screening, new drug research and development, and the current issues faced in this field, aiming to provide a reference for in-depth research in the pharmaceutical industry and related areas of tumor biology.
关键词
肿瘤类器官/抗肿瘤药物研发/高通量药物筛选/个性化医疗
Key words
tumor organoids/anti-tumor drug development/high-throughput drug screening/personalized medicine
维普
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