Degenerative lumbar scoliosis (DLS) is a spinal deformity that occurs primarily in adults.It is characterized by asymmetric degeneration of intervertebral discs and facet joints, leading to spinal imbalance that can result in severe pain and neurological deficits, thus significantly reducing the quality of life.DLS is likely caused by a combination of environmental factors and genetic predisposition.However, the molecular mechanisms driving DLS remain unclear.The focus of this article is to provide an overview of the specific epigenetic and/or genetic factors driving DLS and current challenges in the field, in order to provide a theoretical reference for future research.
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