Advances in the mechanism and clinical application of bone marrow mesenchymal stem cells for the treatment of cerebral infarction
Bone marrow mesenchymal stem cells (BMSCs) have attracted much attention in recent years as a novel therapeutic tool for cerebral infarction.BMSCs exert therapeutic effects primarily through multiple pathways, including replacement and filling, immunomodulation, inhibition of apoptosis, and protection of the blood-brain barrier.This article systematically reviews the mechanisms of BMSCs in the treatment of cerebral infarction, including the mechanisms of gene-modified BMSCs and BMSCs-derived exosome therapy, as well as the mechanisms of BMSCs in combination with other methods of treatment for cerebral infarction.Additionally, the article summarizes the routes, timing and dosages of BMSC transplantation, and the current clinical application of BMSCs in the treatment of cerebral infarction to provide a reference for future clinical research.
万方数据
维普
