摘要
随着肥胖及与其相关的心脏代谢紊乱风险因素的增加,肥胖性心肌病的发病率在全球呈上升趋势.值得注意的是,肥胖性心肌病表现出明显的性别特异性.肥胖性心肌病的发病机制包括胰岛素抵抗、脂质代谢紊乱、炎症反应和线粒体功能障碍等.最新研究证据发现,性别、性激素以及性别特异性分子机制在肥胖性心肌病的发病中都扮演着重要角色.本文对不同性别肥胖性心肌病的发病机制及治疗策略进行综述.
Abstract
In association with the increase in obesity and related cardiometabolic risk factors, the prevalence of obesity-related cardiomyopathy is rising worldwide.Notably, obesity-related cardiomyopathy exhibits significant gender-specific characteristics.The pathogenesis of obese-related cardiomyopathy encompasses insulin resistance, lipid metabolism disorder, inflammatory responses, mitochondrial dysfunction, etc.Recent research has found that gender, sex hormones, and gender-specific molecular mechanisms play important roles in the development of obesity-related cardiomyopathy.This review article discusses the pathogenesis, clinical efficacy, and treatment strategies of obesity-related cardiomyopathy, focusing on gender differences.
基金项目
辽宁省教育厅高校基本科研项目重点攻关项目(LJKZZ20220149)
维普
万方数据