Research progress on cuproptosis in pancreatic cancer
Pancreatic cancer is a highly aggressive and lethal malignancy with a very poor overall prognosis,having a five-year survival rate of less than 10％. In recent years,research on cell death mechanisms has become an emerging focus in pancreatic cancer therapy,especially non-apoptotic forms of regulated cell death. Cuproptosis is a form of regulated cell death triggered by the accumulation of intracellular copper ions and is closely related to mitochondrial metabolism. This review systematically summarizes the uptake and utilization of copper,the regulatory mechanisms of intracellular copper homeostasis,the molecular mechanisms of cuproptosis,and the characteristics of cuproptosis in pancreatic cancer. Additionally,we will explore potential therapeutic strategies targeting cuproptosis,aiming to provide new perspectives for the treatment of pancreatic cancer.
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