铜死亡在胰腺癌中的研究进展
Research progress on cuproptosis in pancreatic cancer
宁振 1谭广1
作者信息
- 1. 大连医科大学附属第一医院普外科,辽宁大连 116011
- 折叠
摘要
胰腺癌是一种具有高度侵袭性和致命性的恶性肿瘤,总体预后极差,5年生存率不足10％.近年来,细胞死亡机制研究成为胰腺癌治疗的新兴热点,特别是非凋亡性调控性细胞死亡形式.铜死亡是一种由细胞内铜离子积累触发的调控性细胞死亡形式,与线粒体代谢密切相关.本文系统综述了铜在胰腺癌中的摄取及利用、细胞内铜稳态调节机制、铜死亡的分子机制,以及胰腺癌中的铜死亡特征及靶向铜死亡的可能治疗模式,以期为胰腺癌治疗带来新的视角.
Abstract
Pancreatic cancer is a highly aggressive and lethal malignancy with a very poor overall prognosis,having a five-year survival rate of less than 10％. In recent years,research on cell death mechanisms has become an emerging focus in pancreatic cancer therapy,especially non-apoptotic forms of regulated cell death. Cuproptosis is a form of regulated cell death triggered by the accumulation of intracellular copper ions and is closely related to mitochondrial metabolism. This review systematically summarizes the uptake and utilization of copper,the regulatory mechanisms of intracellular copper homeostasis,the molecular mechanisms of cuproptosis,and the characteristics of cuproptosis in pancreatic cancer. Additionally,we will explore potential therapeutic strategies targeting cuproptosis,aiming to provide new perspectives for the treatment of pancreatic cancer.
关键词
胰腺癌/铜死亡/预后Key words
pancreatic cancer/cuproptosis/prognosis引用本文复制引用
基金项目
国家自然科学基金面上项目(81972217)
出版年
2024
NETL
NSTL
万方数据