Clinical observation of low-energy laser-assisted minocycline hydrochloride in the treatment of peri-implant mucositis
Objective To evaluate the clinical effect of low-energy laser-assisted minocycline hydrochloride treatment on peri-implant mucositis. Methods A total of 52 patients with peri-implant mucositis who were admitted to Qingdao Hospital of Rehabilitation University (Qingdao Municipal Hospital) from January 2021 to February 2023 were selected as the research objects,including 29 males and 23 females with an average age of (51.35±11.82) years. Patients were randomly divided into control group and experimental group with 26 patients in each group. Control group was treated with mechanical therapy and minocycline hydrochloride;experimental group was treated with mechanical therapy+minocycline hydrochloride therapy+low-energy laser irradiation. The modified plaque index (mPLI),gingival index (GI),modified gingival sulcus bleeding index (mSBI) and probing depth around implants (PPD) were measured and compared at baseline and at 1,3 and 6 months after treatment. IL-6,IL-1β and TNF-α in gingival crevicular fluid of patients in each group were measured at baseline and at 6 months after treatment. Results The mPLI,GI,mSBI and PPD in the experimental group were lower than those in the control group at 1 and 3 months after treatment,and the differences were statistically significant (P<0.05). The mPLI and mSBI in the experimental group were lower than those in the control group at the 6 months after treatment,and the differences were statistically significant (P<0.05);while GI and PPD were lower but did not show statistically significant differences (P>0.05). The levels of IL-6,IL-1β and TNF-α in the experimental group were lower than those in the control group at the 6 months after treatment,and the differences were statistically significant (P<0.05). Conclusions Low-energy laser-assisted minocycline hyd-rochloride has a good therapeutic effect on peri-implant mucositis in the short term,reducing inflammatory cytokines expression and improving periodontal conditions. The approach is worth clinical promotion.
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