功能性水凝胶敷料在糖尿病慢性伤口中的应用研究进展
Progress in the application of functional hydrogel dressings in diabetic chronic wounds
陈观平 1高晶晶 1贾冬 1辛明霞 1邵华1
作者信息
- 1. 大连大学附属新华医院血管外科,辽宁大连 116000
- 折叠
摘要
糖尿病足溃疡(DFU)是因糖尿病所致的足踝以下溃疡或深层组织破坏,是糖尿病最严重的并发症之一,具有高截肢率、复发率和死亡率.目前,传统外科清创、抗感染等治疗以及高压氧、负压治疗等革新疗法已经成为预防截肢的重要手段,然而DFU的治愈率仍不理想.水凝胶敷料凭借其良好的保湿性、生物相容性等优点,成为创面敷料应用领域中的研究热点.本文基于DFU的微环境、溃疡创面难愈合的因素、湿性愈合理论对功能性水凝胶敷料治疗DFU的进展作一综述.
Abstract
Diabetic foot ulcer (DFU) is a serious complication of diabetes,characterized by ulcers or deep tissue destruction below the ankle in diabetic patients. It is associated with high amputation rate,recurrence rate and mortality rate. Currently,traditional surgical treatments such as debridement and anti-infection,as well as innovative therapies such as hyperbaric oxygen and negative pressure therapy,have become important tools for the prevention of amputation. However,the cure rate of DFU is still unsatisfactory. Hydrogel dressings have emerged as a research hotspot in the field of wound care due to their excellent moisture retention,biocompatibility and therapeutic properties. Focusing on the microenvironment of DFU,the factors that make ulcer wound difficult to heal,and moist wound healing therapy,the progress of DFU functional hydrogel dressing treatment is reviewed in this paper.
关键词
糖尿病足溃疡/伤口微环境/慢性伤口愈合/湿性愈合理论/水凝胶/敷料Key words
diabetic foot ulcer/wound microenvironment/chronic wound healing/moist wound healing therapy/hydrogel/dressing引用本文复制引用
基金项目
吴阶平医学基金会临床科研专项资助基金项目(320.6750.2023-11-46)
出版年
2024
NETL
NSTL
万方数据