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结直肠锯齿状病变的研究进展

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结直肠锯齿状病变(CSL)是一类隐窝上皮呈锯齿状特征的异质性病变,根据WHO最新分类标准,CSL主要分为增生性息肉(HP)、无蒂锯齿状病变(SSL)和传统锯齿状腺瘤(TSA),后两者为结直肠癌(CRC)主要的癌前病变类型.通过锯齿状途径发生的癌变约占CRC的1/3.本文主要对CSL的病理分类、癌变途径、诊断、治疗及随访监测等方面进行综述,旨在提高对CSL的认识,为CRC的防治提供新思路.
Research progress of colorectal serrated lesions
Colorectal serrated lesions (CSL) are a heterogeneous group of lesions characterized by serrated features in crypt epithelium. According to the latest WHO classification standards,CSL are mainly divided into hyperplastic polyps (HP),sessile serrated lesions (SSL) and traditional serrated adenomas (TSA),with the latter two being the main types of precancerous lesions in colorectum. Approximately one-third of colorectal cancer cases develop through the serrated pathway. This article mainly focuses on the pathological classification,carcinogenetic pathways,diagnosis,treatment,and follow-up monitoring of CSL,aiming to improve the understanding of CSLs and provide a new perspective for the prevention and treatment of colorectal cancer in the future.

colorectal serrated lesionscolorectal cancerendoscopic featuresmolecular pathway

王上元、姜春萌

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大连医科大学研究生院,辽宁大连 116044

大连医科大学附属第二医院消化一科,辽宁大连 116027

锯齿状病变 结直肠癌 内镜特征 分子途径

2024

大连医科大学学报
大连医科大学

大连医科大学学报

CSTPCD
影响因子:0.797
ISSN:1671-7295
年,卷(期):2024.46(4)
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