The Signals and Systems course has many concepts,and related mathematical theories are relatively abstract and difficult to understand.Python is one of the most favorite open-source languages,it's simulation program can visually present related concepts and theories,making it easy for students to learn in the classroom.On the basis of the comparative analysis of the existing programming languages,the necessity and feasibility of Python application in the teaching of Signals and Systems are obtained.Finally,Python's symbolic library sympy is employed to simulate continuous-time signals and systems.It is verified that Python can well meet the needs of the teaching of Signals and Systems.