Protective effect of penehyclidine hydro-chloride preconditioning on myocardial injury resulting from ischemia-reperfusion in rabbits
AIM: To study the effect of penehyclidine hydro-chloride preconditioning on myocardial injury resulting from ischemia-reperfusion in rabbits. METHODS: Twenty-four New Zealand white rabbits were randomly allocated to 3 groups (n = 8 in each group) : control group (group C) with myocardial ische-mia-reperfusion; the other two groups were pretreated with aniso-damine hydrobromide (group A) and penehyclidine hydrochloride (group P) respectively. Each group was subjected to 1 h of occlusion of left anterior descending artery followed by 3 h reperfu-sion. Myocardial ultrastructure was examined under electron microscope; myocardial infarct size was measured by nitroblue tet-razolium at the end of the experiment. RESULTS: Myocardial infarct size was much smaller in group P and A than in group C, and there was no significantly difference between group P and A; the mitochondria showed significant edema and more severe damage in group C than in group P and A. CONCLUSION: The preconditioning with penehyclidine hydrochloride or anisodamine hydrobromide has the myocardial protective effect against ischemia-reperfusion injury in rabbits.
NETL
NSTL
万方数据
维普
