短期跑步训练对中老年及老年大鼠空间学习能力的作用
Effects of short-term running exercise on spatial learning capacity of middle-aged and aged rats
卢伟 1杨俊卿 2杨姝 3李琛 3张伟 1师晓燕 3陈林 1徐玲 1唐勇3
作者信息
- 1. 重庆医科大学组织学与胚胎学教研室,重庆,400016;重庆医科大学干细胞与组织工程学教研室,重庆,400016
- 2. 重庆医科大学干细胞与组织工程学教研室,重庆,400016
- 3. 重庆医科大学组织学与胚胎学教研室,重庆,400016;重庆医科大学干细胞与组织工程学教研室,重庆,400016;重庆医科大学附属第一医院神经内科,重庆,400016
- 折叠
摘要
目的:探讨跑步训练对中老年及老年雌、雄性大鼠空间学习能力的作用.方法:将14 mo龄和24 mo龄的雌、雄性SD大鼠随机分为跑步训练组与空白对照组,前者进行跑步训练4 mo,后者在普通环境中饲养4 mo后,测试其在Morris水迷宫中的表现.结果:跑步训练至18 mo龄的雌性大鼠空间学习能力显著强于同月龄的空白对照组,但跑步训练至18mo龄的雄性大鼠空间学习能力与空白对照组相比并无显著性的差异.跑步训练至28 mo龄的雌、雄性大鼠空间学习能力与空白对照组相比均不存在显著性的差异.结论:短期跑步训练可使中老年雌性大鼠的空间学习能力显著提高,这一结论为今后运用跑步锻炼等手段来延缓老年人大脑功能下降的进程提供了重要的理论依据.
Abstract
AIM: To investigate the effects of short-term running exercise on the spatial learning capacity of middle-aged and aged rats. METHODS: Fourteen months and twenty-four months aged male and female SD rate were randomly assigned to running group and control group. The rats in running group took treadmill exercise for 4 months. The rats in control group were housed under standard condition for 4 months without running. The spatial learning capacity of animals in both running group and in control group was then assessed using Morris Water Maze. RESULTS: The running exercise significantly improved the spatial learning capacity of the 18-month female rats, but the difference in the spatial learning capacity of the 18-month male rats between running group and control group was not statistically significant. The spatial learning capacity of the 28-month male and female rats between running group and control group was not significantly different. CONCLUSION: Short-term running exercise remarkably improves the spatial learning capacity of middle-aged female rats. This result provides an important theoretical basis for the application of similar strategy to delay the progress of brain function decline with aging.
关键词
大鼠/空间学习能力/跑步训练/morris水迷宫Key words
rats/spatial learning capacity/running exercise/morris water maze引用本文复制引用
基金项目
国家自然科学基金(30440082)
国家自然科学基金(30572075)
国家人事部高层次留学人才回国工作经费资助项目()
教育部重点科研项目()
教育部留学回国人员科研启动基金()
重庆市自然科学基金(CSTC)
重庆市自然科学基金(2005BB5034)
重庆市教育委员会资助项目(KJ070319)
出版年
2009
NETL
NSTL
维普
万方数据