Preparation and quality control of vitamin E microsphere gels
AIM: To prepare vitamin E microsphere gels and to establish the quality control method. METHODS: Four factors and three levels of orthogonal design were used to optimize the prescription. Second derivative ultraviolet spectroscopy method was used to determine the vitamin E content. RESULTS: The prepared gels met the descriptions of China Pharmacopeia (2005 edition) in property and identification, etc. The linear range of vitamin E was 0.1-0.4 g/L( r = 0.9994) and the average recovery rate was 99.2% ( RSD = 0.75% , n = 9). CONCLUSION: The established technique of this preparation is simple and feasible, and its quality is stable and controllable.
vitamin Emicrospheresgelsdrug compoundingquality control
NETL
NSTL
万方数据
维普
