Effects of bisoproloi on kaliuretic peptide, plasma renin activity and atrial natriuretic peptide in patients with chronic congestive heart failure
AIM: To investigate the levels of kaliuretic peptide (KP) , plasma renin activity (PR A) and atrial natriuretic peptide (ANP) in patients with chronic congestive heart failure (CHF) and to evaluate the beneficial effects of beta-blockers on the variables mentioned above. METHODS: One hundred and twenty patients with CHF were divided into two subgroups randomly. Routine group was treated with routine drugs ( ACE inhibitors, diuretics and digoxin, n = 60) , while bisoprolol group was given beta-blocker( bisoprolol, n = 60) additionally. The levels of plasma KP, PRA and ANP were detected by radioimmunoassay and the left ventricular ejective fraction ( LVEF) was measured by nuclide ventricular imagery in patients with CHF, as well as subjects in control group(healthy people, n = 60). RESULTS: The levels of KP, PRA and ANP in patients with CHF were much higher than those in the control group at each time point during the course. Significantly negative correlations were found between KP, ANP and LVEF 12 weeks after treatment (rKP = - 0. 34, rANP = -0.31, P <0.05) and great differences were observed in KP level between NYHA Ⅱ , Ⅲ and Ⅳ patients with CHF. The levels of KP, PRA and ANP in bisoprolol group were significantly lower than those in routine group ( P < 0.05 ). CONCLUSION: KP and ANP might play an important role in the pathogenesis of CHF and their levels can serve as guide for the treatment of CHF even after beta-blockers therapy. Beta-blockers suppress the over-activation of neurohumoral system in patients with CHF.
NETL
NSTL
万方数据
维普
