Comparison of coagulative function between patients with liver cirrhosis and those with cirrhosis complicated with hepatocellular carcinoma receiving liver transplantation
AIM: To compare the coagulative function between patients with cirrhosis complicated with hepatocellular carcinoma (HCC) and patients with liver cirrhosis so as to modulate the perioperative coagulative function more effectively. METHODS: In 37 patients of liver cirrhosis complicated with HCC (group C) and 40 patients with simple liver cirrhosis (group Ⅴ) , who were undergoing liver transplantation, TEG was employed to determine the R, K and MA values and α angle after anesthesia( phase Ⅰ ), anhepatic phase (phase Ⅱ ) and 90 min after neohepatic phase ( phase Ⅲ ). Blood loss and consumption of blood products in the 3 phases were recorded. RESULTS: In phase Ⅰ and Ⅱ, the MA value and a angle of group C were significantly higher than those in group Ⅴ, the blood loss in group C was markedly lower than that in group Ⅴ and the volume of transfused blood products ( FFP) in phase Ⅰ in group C was lower than that in group Ⅴ ( P < 0.05). In phase Ⅲ, the coagulative function in both groups reduced. The R value was higher but MA value and a angle were lower compared with the preoperative values, respectively(P <0.05) but the consumption of blood products of group C was remarkably lower than that in group V(P < 0. 05). CONCLUSION: Compared with those of the patients with simple cirrhosis, the perioperative coagulative function of patients with liver cirrhosis complicated with HCC is better and blood loss and volume of transfused blood products are lower.
liver transplantationliver cirrhosiscarcinomahepatocellularcoagulative function
NETL
NSTL
万方数据
维普
