Surgery combined with preoperative and postoperative radiotherapy for rectal carcinoma
AM: To assess the therapeutic effect of surgery combined with preoperative and postoperative radiotherapy ("Sandwich" treatment) on rectal carcinoma. METHODS: In "Sandwich" group(A, n = 92): preoperative accelerated hyper-fractionation(15 Gy/6 f/3 d) and conventional postoperative frac-tionation(DT 35-40 Gy/3. 5-4 w) were given according to their postoperative pathological results. Patients in group B (n = 98) were given postoperative radiotherapy ( DT 50 Gy/5 w). Patients treated with surgery alone served as control ( C, n = 70 ). RESULTS: Follow-up rate reached 96.4%. The local recurrence rates of group A, B and C were 5.4% (5/92), 16. 3% (16/98) and 64. 3% (45/70), respectively ( P < 0. 05 ) and the distant metastasis rates were 6.5% (6/92), 28.6% (28/98)and 31.4% (22/70 ) , respectively ( P < 0. 01 ). The 3-year survival rates were 86.9% ( 80/92 ) , 62. 2% (61/98) and 51. 4% (36/70 ) , respectively (P <0.01) and the 5-year survival rates were 68.5% (63/92) , 54. 1% (54/98) and 41. 4% (29/70) , respectively (P < 0.05 ). The rates of grade Ⅰ and grade Ⅱ radiation entero-colitis in group A and B were 7.6% (7/92) and 6. 1% (6/98) , respectively ( P > 0. 05 ). CONCLUSION: Surgery combined with preoperative and postoperative radiotherapy improves the survival rate and reduces the local recurrence rate in patients with stage Ⅱ and stage Ⅲ rectal carcinoma.
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万方数据
维普
