Influence of Nourishing Yin Antitoxic Capsule on adrenocortical cell apoptosis and TNF-α in Yin deficiency rats induced by hydrocortisone
AIM: To identify the underlying mechanisms of adrenal function recovery by Nourishing Yin Antitoxic Capsule (YC) in Yin-deficiency syndrome rats. METHODS: Thirty rats were separated into three groups: control group, hydrocortisone model group and YC treatment group. TUNEL was employed to display apopotic cells in situ. The level of TNF-α was measured by RT-PCR. RESULTS: Compared to control group, hydrocortisone group had increased apoptotic rate and level of TNF-α, which were reversed by YC. CONCLUSION: YC inhibits the adrenocortical cell apoptosis and the decrease of TNF-α level induced by hydrocortisone, which contributes to adrenal function recovery.
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万方数据
维普
