Analysis of clinicai diagnosis and treatment and pathological characteristics of acute rejection following orthotopic liver transplantation
AIM: To investigate the clinical diagnosis and treatment as well as pathological characteristics of acute rejection following orthotopic liver transplantation (OLT). METHODS: A retrospective analysis was conducted on pathohistological changes, clinical manifestations and treatment plans in 516 cases of acute rejection following OLT from January 2004 to December 2006 at the First Affiliated Hospital of Sun Yat-sen University. RESULTS : A total of 106 episodes of acute rejections happened in 86 cases of the 516 OLT recipients (16. 7% ). Of the 106 episodes , 9 were borderline, 36 mild (Banff Ⅰ ), 48 midrange ( Ⅱ ) and 13 severe rejection (Ⅲ ). Thirty-six of the 106 episodes were controlled by drug dosage adjustment, 65 were controlled by MP stoss therapy and 5 failed the MP stoss therapy, of whom 3 recipients received OKT3 and 2 underwent re-transplantation. CONCLUSION : Acute rejection following OLT is short of typical signs and symptoms. Craft biopsy is still the " gold standard" to diagnose acute rejections. Designing individual-tailored immunosup-pressive regime plays an important role in increasing the long-term surviving rate of OLT patients.
NETL
NSTL
万方数据
维普
