Coagulation functions in rabbits with spinal cord ischemia-reperfusion injury and effect of glutamine precondition
AIM: To explore the changes of coagulation functions in rabbits with spinal cord ischemia-reperfusion injury (SCI-RI) and the effect of glutamine precondition. METHODS: SCI-RI model were established with Zivin method in rabbits. PT, APTT, TT and FIB were measured at different time point before and after injury. RESULTS: FT, APTT, TT and FIB of rabbits with SCIRI increased obviously, reached the peak value after reperfusion of 2 hours, then started to decrease and reached the level below pre-ischemia value at the 12th hour after reperfusion. In the process, except PT, the other 3 indices were significantly higher at 45 min, 2 and 6 h than those pre-ischemia ( P < 0.01). PT, APTT, TT and FIB of rabbits with SCIRI with glutamine precondition were lower than those without glutamine precondition, but with no statistically significant differences. CONCLUSION: SCIRI leads to significant changes of coagulation functions and glutamine precondition fail to improve them.
glutaminespinal cordischemia-reperfusion injurycoagulation function
NETL
NSTL
万方数据
维普
