Immunosuppressive effects of emodin on skin transplantation in mice
AIM: To investigate the immunosuppressive effects of emodin on skin transplantation in mice and its immunosuppres-sive mechanism. METHODS: C57BL/6→BALB/c skin transplantation models were established and then treated with different concentrations of emodin and cyclosporine A (CsA ). The different mean survival times ( MST) of different groups were observed. Changes of plasma cytokines (IL-2) in mouse skin transplantation models were determined by ELISA and histological changes at different concentrations of emodin and cyclosporine A ( CsA ) were investigated. RESULTS: In the group treated with emodin, the MST of skin graft was prolonged and production of plasma IL-2 decreased. The histological results suggested that emodin relieved the graft immunological damage in a dose-dependent manner and exerted synergistic effect with CsA. CONCLUSION: Emodin exerts some immunosuppressive effects on mouse skin transplantation possibly by suppressing IL-2.
NETL
NSTL
万方数据
维普
