RECK及MMP-2在膀胱移行细胞癌中的表达及其与侵袭复发的关系
Expression of RECK and MMP-2 in transitional cell carcinoma of bladder and its correlation with cancer invasion and recurrence
郝斌 1张波2
作者信息
- 1. 华中科技大学同济医学院附属同济医院泌尿外科,湖北武汉,430030;郑州大学第二附属医院泌尿外科,河南郑州,450014
- 2. 郑州大学第二附属医院泌尿外科,河南郑州,450014
- 折叠
摘要
目的:探讨RECK及MMP-2在膀胱移行细胞癌中的表达及临床意义.方法:采用免疫组化法检测42例膀胱移行细胞癌及13例正常膀胱黏膜组织中RECK及MMP-2的表达.结果:在肿瘤组织中RECK的表达阳性表达率为52%(22/42),明显低于正常膀胱黏膜组织(85%,11/13),而MMP-2在癌组织中的阳性表达率为74%(31/42),明显高于正常膀胱黏膜组织(23%,3/13)(P<0.05).RECK随临床病理分期升高及复发而表达降低(P<0.05),MMP-2表达随肿瘤组织学分级、病理分期和肿瘤复发显著升高(P<0.05).RECK与MMP_2表达旱负相关.结论:RECK和MMP-2的表达与膀胱移行细胞癌的侵袭、转移和复发密切相关,可作为膀胱移行细胞癌预后判断的生物学指标.
Abstract
AIM: To investigate the expression of RECK and MMP-2 in transitional cell carcinoma of the bladder (BTCC) and its clinical significance. METHODS: The expression of RECK and MMP-2 protein was detected in 42 cases of tumor and 13 cases of normal bladder tissue by immunohistochemical method. RESULTS: The frequency of RECK protein expression was observed in 22 of the 42 (52% ) cases of BTCC, significantly lower than that in normal bladder mucosa ( 85%, 11/13) (P<0.05), while that of MMP-2 protein expression in BTCC (74% ,31/42) was higher than that in normal bladder mucosa (23% , 3/13) (P <0.05). Along with the progression of pathological stages and tumor recurrence, the positive expression rate of RECK in tumors descended obviously (P<0.05). The positive expression rate of MMP-2 increased obviously along with the progression of the tumor, differentiation grade and pathological stage, as well as the tumor recurrence. A negative correlation was observed between the expression of RECK and MMP-2. CONCLUSION: The expression of RECK and MMP-2 correlates closely with the capacities of invasion, metastasis and recurrence of transitional cell carcinomas of the bladder and can be used as a new biological marker to predict the prognosis.
关键词
膀胱肿瘤/癌,移行细胞/RECK/明胶酶A/免疫组织化学Key words
bladder neoplasms/carcinoma/transitional cell/RECK/gelatinase A/immunohistochemistry引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据