Expression of RECK and MMP-2 in transitional cell carcinoma of bladder and its correlation with cancer invasion and recurrence
AIM: To investigate the expression of RECK and MMP-2 in transitional cell carcinoma of the bladder (BTCC) and its clinical significance. METHODS: The expression of RECK and MMP-2 protein was detected in 42 cases of tumor and 13 cases of normal bladder tissue by immunohistochemical method. RESULTS: The frequency of RECK protein expression was observed in 22 of the 42 (52% ) cases of BTCC, significantly lower than that in normal bladder mucosa ( 85%, 11/13) (P<0.05), while that of MMP-2 protein expression in BTCC (74% ,31/42) was higher than that in normal bladder mucosa (23% , 3/13) (P <0.05). Along with the progression of pathological stages and tumor recurrence, the positive expression rate of RECK in tumors descended obviously (P<0.05). The positive expression rate of MMP-2 increased obviously along with the progression of the tumor, differentiation grade and pathological stage, as well as the tumor recurrence. A negative correlation was observed between the expression of RECK and MMP-2. CONCLUSION: The expression of RECK and MMP-2 correlates closely with the capacities of invasion, metastasis and recurrence of transitional cell carcinomas of the bladder and can be used as a new biological marker to predict the prognosis.
NETL
NSTL
万方数据
维普
