Dose-dependent effect difference of partial liquid ventilation for dogs with inhalation injury
AIM: To explore the difference of dose-dependent effect of partial liquid ventilation (PLV) in treatment of dogs with steam inhalation injury. METHODS: Fifteen healthy dogs with steam inhalation injury were randomly divided into two groups: PFC 6 mL/kg group (PFC-6) and PFC 12 mL/kg group (PFC-12). Parameters of blood gas and hemodynamics at 30, 60 and 90 min after PLV were recorded. Concentration of ceruloplasmin (CP) and malondialdehyde (MDA) in serum, total protein (TP) , albumin (ALB) , globulin (GLB) , CP in bronchoalveolar lavage fluid and lung homogenate were detected at 2 h after PLV. RESULTS: PaO2 in PFC-6 improved significantly at 30 min after PLV and PaO2 in PFC-12 improved significantly at 30, 60 and 90 min after PLV (P<0.05). The improvement of PaO2 in PFC-12 was not significantly different (P>0.05), though. No obvious changes were observed in PaCO2, HR, MAP and CVP in the two groups at any time points after PLV ( P > 0.05). At 2h after PLV, CP and MDA in serum were not significantly different between PFC-12 and PFC-6 groups (P >0. 05). TP, ALB and GLB in bronchoalveolar lavage fluid and in lung homogenate decreased significantly in PFC-12 compared with those in PFC-6 ( both P < 0.05) but CP increased significantly (P < 0. 05 ). CONCLUSION: PLV is a new ventilation technology, which significantly improves PaO2 in inhalation injury and exerts no impairment on hemodynamics. PLV shows no dose-dependent effect difference in improving oxygenation. PLV may decrease leakage of serum protein in dogs with inhalation injury by anti-lipid peroxi- dant with a dose-dependent effect difference.
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