Prognostic significance of CD20 expression in adults with precursor B-lineage acute lymphoblastic leukemia
AIM: To study the prognostic significance of CD20 expression in 91 adults with precursor B-lineage acute lymphoblastic leukemia(pre-B-ALL). METHODS: The clinical characteristics and outcome of 91 acute lymphoblastic leukemia patients admitted to our hospital between January, 2005 and January 2008 were analyzed. The complete remission (CR) rate, continued complete remission rale, extramedullary infiltration rate, relapse rate, and 2-year overall survival rate were compared between CD20 positive and negative patients. RESULTS: Out of the 91 patients, there were 43 (47% ) patients with CD20 positive and 48 (53% ) patients with CD20 negative. Out of the 91 patients, CR in CD20 positive and CD20 negative after the first induction cycles was 69.8% (30/43) and81.3% (39/48, P>0.05) and continued complete remission rate was 11. 6% (5/43) and 41. 7% respectively (20/48, P<0.05). The rate of extramedullary infiltration was 46. 5% (20/43) and 22. 9% respectively (11/ 48, P<0.05), relapse rate was 65. 1% (28/43) and 39.6% respectively (19/48, P <0. 05) and 2-year overall survival was 17.3% and 47.2% respectively (P<0.05). CONCLUSION: CD20 expression in adult pre-B-ALL cells appears to be associated with poor prognosis.
NETL
NSTL
万方数据
维普
