12C6+重离子束照射治疗复发性软组织肉瘤临床疗效探讨
Recrudescent soft tissue sarcoma treated by 12C6+ heavy ion beam radiotherapy
魏世华 1李莎 1张红 2岳养军 1田种泽 1李强 2陈小华1
作者信息
- 1. 兰州军区兰州总医院放射治疗科,甘肃,兰州,730050
- 2. 中国近代物理研究所,甘肃,兰州,730000
- 折叠
摘要
目的:应用我国自主研发的重离子加速器产生的12C6重离子束治疗复发性软组织肉瘤,评价其高线性能量传递(LET)及低LET在临床应用中的优劣.方法:3例经病理证实为软组织肉瘤自愿接受重离子束照射的患者,其中2例病变位于腹部,1例在背部.所有患者均为手术复发2次以上,最多达6次,并经手术行常规放疗失败.应用80～100 mev/u重离子束对3例患者分别给予总剂量72～120 GyE/6-12 f照射,生物效应剂量(RBE)=3.结果:2例患者3 mo后病变完全消失,达临床治愈;1例缩小75%,达临床部分缓解,总有效率为100%.治疗中及治疗后照射野皮肤无破溃等放射性损伤.结论:12C6+重离子束具有治疗精度高,疗程短,对肿瘤周围正常组织损伤小等特点.特别在射线抗拒的难治性肿瘤中可达到常规放疗难以实现的疗效,具有很好的临床应用前景.
Abstract
AIM: To report the treatment of recrudescent soft tissue sarcomas by China-made heavy ion accelerator of the 12C6+ heavy ion beam and to evaluate the pros and cons of high-ami low-LET radiotherapy in the clinical application. METHODS: Three patients pathologically diagnosed as having soft tissue sarcoma, two in the abdomen and one in the back, voluntarily took heavy ion beam radiotherapy. All 3 cases were recurrent patients, who had had surgical and radiotherapy treatment but no good results. Each of the patients was exposed to 80-100mev/u heavy ion beam, a total dose of 72-120GYE/6-12f (RBE = 3). RESULTS: Three months after the treatment, tumors disappeared in two of the three cases, evaluated clinically as complete recovery, and in the other one case, the tumor reduced by 75% in size, evaluated clinically as partial recovery. The total effective rate was 100% and no radioactive damage of irradiation was observed in normal tissues during or after radiotherapy. CONCLUSION: 12C6+ heavy ion beam has the advantage of high accuracy, short course of treatment, and slight lesion of normal tissues round sarcoma, especially in some ray-resistant refractory tumors for conventional radiotherapy.
关键词
肉瘤/12碳6+重离子/线性能量传递(LET)/放射治疗Key words
sarcoma/12C6+ heavy ion/high LET/radiotherapy引用本文复制引用
基金项目
国家高技术研究发展计划(863计划)(2006AAo2z499)
国家自然科学基金(10675151)
出版年
2009
NETL
NSTL
维普
万方数据