Expression of CD133 in hepatocellular carcinoma and its significance
AIM: To assess the significance of CD133 expression in hepatocellular carcinoma ( HCC ) and its correlation with clinical features and prognosis of the tumor. MKTHODS: Fifty-two cases of HCC and 6 cases of normal liver specimens were evaluated by two-step methods of Envision immunohistochemical staining against CD133 and Ki-67. Correlation study was conducted between the expressions of CD133 and Ki-67 and clinicopatho-logical and survival rates after hepateetomy. RESULTS: The average intensity of CD133 expression on 52 HCCs was 1. 07 ± 0.32. The CD133 expressions were significantly associated with histological grades and clinical stages (F = 62.96 & 57. 13, P < 0. 05) , but not with age, gender and tumor size. The Ki-67 positive expression rate was 57. 7% in HCC. The Ki-67 expressions were also significantly associated with histological grades and clinical stages(F = 8.56 & 7.45, P<0.05). There was a positive correlation between the expressions of CD133 and Ki67 ( F — 18.37, P < 0.05). The survival time of CD133 negative patients was significantly longer than that of CD133 positive patients(P < 0.05). CONCLUSION: CD133 expression correlates positively with the progression of HCC and may potentially serve as a marker for HCC prognosis.
NETL
NSTL
万方数据
维普
