玉屏风散加味治疗慢性荨麻疹的作用及机制
Suppressing effect of Yupingfeng Powder Prescription in treatment of chronic urticaria
李旭波 1李娜 2侯颖 1刘水冰 1刘菁菁 1耿铮1
作者信息
- 1. 第四军医大学药学系药理学教研室,陕西,西安,710033
- 2. 西安医学院第二附属医院皮肤科,陕西,西安,710068
- 折叠
摘要
目的:探讨玉屏风散(YPP)加味治疗慢性荨麻疹的作用机理.方法:采用随机对照法,将SD大鼠,NIH小鼠随机分为对照组,模型组,开瑞坦组,YPP加味高(4 g/L)、中(2g/L)、低(1 g/L)剂量组.检测对大鼠同种被动皮肤过敏反应(PCA)的影响及对小鼠皮肤毛细血管通透性、小鼠血清总IgE,右旋糖酐敛小鼠瘙痒的影响.结果:模型组PCA A值、血清IgE含量、毛细血管通透性的A值明显高于对照组,开瑞坦组;YPP加味各剂量组与模型组比较,A值及血清IgE含量明显下降(P<0.05);模型组瘙痒次数、瘙痒时间明显高于对照组;开瑞坦组,YPP加味各剂量组与模型组比较,瘙痒次数、瘙痒时间明显降低(P<0.05);并且YPP加味4g/L组效果最好,优于开瑞坦组.结论:YPP加味对PCA,血清总IgE含量,皮肤瘙痒次数和时间,毛细血管通透性均有抑制作用.
Abstract
AIM: To investigate the mechanism of Yupingfeng Powder Prescription in the treatment of chronic urticaria. METHODS: To observe the inhibitory effect of Yupingfeng Powder Prescription ( YPP) on rat passive cutaneous anaphylaxis (PCA), the relativity of immunoglobulin E( IgE), the times of ruritus of the mice, and Histamine-induced skin on the permeability of capillary. RESULTS : Compared with those in the normal group, the PCA absorbance, IgE levels in serum and capillary permeability of the absorbance increased significantly in the model group(P <0.05). Compared with those in the model group, the PCA absorbance and IgE levels in serum decreased, and the number of itching and itching durations significantly reduced in each treatment group (P < 0. 05). CONCLUSION: Yupingfeng Powder Prescription effectively reduces the serum IgE levels and inhibits capillary permeability and skin itching durations of rats with passive cutaneous anaphylaxis.
关键词
慢性荨麻疹/玉屏风散加味/被动皮肤过敏反应/IgE蛋白/毛细血管通透性/肠粘膜形态学Key words
chronic urticaria/Yupingfeng powder prescription/PCA/IgE/vascular permeability/mucosal morphology引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据