土鳖虫对2型糖尿病大鼠模型血糖、血脂的的影响
Effects of Eupolyphaga Sinensis Walker on rats of type 2 diabetes
张晶 1许贵香2
作者信息
- 1. 第二军医大学长海医院药学部,上海,200433
- 2. 上海市南华医院药剂科,上海,201300
- 折叠
摘要
目的:研究土鳖虫(ESW)对链脲佐菌素(STZ)所致的大鼠2型糖尿病模型血糖、血脂水平变化的影响.方法:采用长期高脂肪乳剂饲养(10 mL/kg,10 d)加小剂量STZ(30ms/kg,ip 1次)诱导大鼠2型糖尿病动物模型,随机将动物分为4组:正常对照组,模型组,阳性对照二甲双胍组,ESW组,每组大鼠10只,各组均为灌胃给药.实验第11日大鼠尾部静脉取血测血糖,1次/wk,连续4 wk;第4 wk取血离心并计算各脏器系数.结果:与模型组相比较,ESW组大鼠血糖值明显降低;血脂TC,TG,LDL-C水平下降,HDL-C水平升高.ESW能纠正2型糖尿病大鼠模型引起的脾脏质量的减少,不能纠正2型糖尿病大鼠模型引起的胸腺萎缩.结论:ESW具有降低2型糖尿病大鼠模型血糖的作用;抑制ACA水平,降低血浆TC,TG,LDL-c的水平及升高HDL-c的水平.
Abstract
AIM: To study the effect of Eupolyphaga Sinenisis Walker(ESW) on blood sugar and blood fat levels in rat model of type 2 diabetes. METHODS: Type 2 diabetes model was induced by ip high fat fodder(10 mL/kg, 10 days) and a little volume of STZ ( 30 mg/kg). The animals were divided into 4 groups: Normal control, model, Metformin positive control and ESW group, with 10 in each group. The blood sugar level was determined once a week for 4 weeks. In the 4 th week, the organ indices were also determined. RESULTS: The diabetes models were established. In ESW group, the levels of blood level obviously reduced, blood fat TC, TG and LDL-C levels dropped, and the HDL-C levels elevated, compared with those in model group. ESW corrected the spleen quality reduction but failed to correct the thymus atrophy in type 2 diabetes rate. CONCLUSION: ESW reduces the levels of blood sugar, plasma TC, TG and LDL-C, inhibits the level of serum ACA and increases the level of HDL-C in type 2 diabetes rat models.
关键词
土鳖虫/2型糖尿病/降血糖/链脲佐菌素Key words
eupolyphaga sinenisis walker/diabetes/reduced the blood sugar/Streptozotocin引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据