Effects of bFGF on expression of CREB in hippocampus and cortex during cerebral ischemia and reperfusion in rats
AIM: To investigate the expression of cyclic AMP response element binding protein ( CREB) in hippocampus and cortex after cerebral ischemia and reperfusion in rats and to explore the regulative effects of basic fibroblast growth factor ( bF-GF)on CREB in brain tissue and its mechanism. METHODS: The rat models of middle cerebral arteries occlusion ( MCAO) were established with intraluminal filament blockade. The expression of CREB and apoptosis of neurons in hippocampus and cortex were detected with immunohistochemistry and TUNEL method respectively. RESULTS: The expression of CREB in hippocampus and cortex decreased after cerebral ischemia and reperfusion. In bFGF group, the expression of CREB increased while cell apoptosis decreased. CONCLUSION: bFGF depresses cell apoptosis, participates in the regulation of CREB expression in ischemic neurons and protects ischemic neurons.
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万方数据
维普
