Experimental study of effects of an an ti-Endoglin monoclonal antibody for pancreatic carcinoma cell xenografts in nude mice
AIM: To observe the inhibitory effect of anti-Endog-lin monoclonal antibody on tumor growth of pancreatic carcinoma. METHODS: We established an animal model of human pancreatic carcinoma in nude mice and the tumor inhibiting activity of anti-Endoglin monoclonal antibody was tested. Forty-four nude mice of human pancreatic carcinoma were randomly assigned to 2 groups: antibody group in which the mice were treated with monoclonal antibody and saline group in which the mice were given normal saline. The tumor volume and the tumor growth inhibition rate were calculated and the tumor was histopathlogically measured. RESULTS: Compared with that in control group, the general state of the mice in antibody group was better and the growth of human pancreatic carcinoma cell PC-3 in antibody group was dramatically inhibited. Compared with that in normal saline group, the growth of the tumor was significantly reduced in size in the mice treated with anti-Endoglin monoclonal antibody, with an inhibition rate of 67. 13%. CONCLUSION: The anti-Endoglin monoclonal antibody has a significant inhibitory effect on mouse pancreatic carcinoma cell PC-3, t indicating that the anti-Endoglin monoclonal antibody is a promising biological treatment for pancreatic carcinoma.
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