Spatio-temporal expression of CD44 during odontogenesis in mice
AM:To study the expression and function of CD44 in different development stages of mouse tooth germ. METHODS: Immunohistochemistry was adopted to detect the expression of CD44 at the bud stag, cap stag, bell of initial morphogenesis stage,bell of differetiational stage, bell of secretory stage, and bell of maturative stage of mouse tooth germ. RESULTS: At the bud, cap stages, a weak or negative expression of CD44 was seen in oral epithelial, dental lamina, enamel organ, dental papilla, and dental follicle. During the bell stage, the expression of CD44 was strong positive in oral epithelim, dental lamina, was weak positive in the outer enamel epithelium, stellate reticulum and od-ontoblasts and was positive in the secretory ameloblasts and dental follicle. The expression of CD44 was strong positive in stratum intermedium at the bell of differetiational stage, bell of secretory stage, and bell of maturative stage of mouse tooth germ. CONCLUSION: CD44 is involed in tooth morphogensis and cell differentiation. The results suggest that CD44 may play a significant role in enamel mineralization and be associated with the formation of root and periodontal tissues.
NETL
NSTL
万方数据
维普
