Experimental study of Alstonia scholaris on mice model of chronic bronchitis
AIM: To investigate the mechanism of Alstonia scholaris in the treatment of chronic bronchitis in mice. METHODS: Extract of Alstonia scholaris (200 g) was boiled down to 100 mL. Mice were divided into 6 groups (10 mice in each) at random: model group, the high, middle or low dose Alstonia scholaris groups, Cuilong group and the control group. Except for the control group and model group, the other four groups were intervened with high, middle or low doae of Alstonia scholaris, and Guilong respectively. Then to determine Activities of SOD and GSH-Px, MDA contents in lung tissues and MPO contents , and changes of immune organ in serum were determined in each group. Pathological changes were also observed with HE staining under microscope. RESULTS: Compared with those in the model group, the activity of SOD and GSH-Px in lung tissues of the drug intervened groups increased obviously, the contents of MDA and MPO decreased significantly, and thymus index and spleen index increased apparently. HE staining showed the alleviation of injury from chronic bronchitis treated with Alstonia scholaris particles. CONCLUSION: Alstonia scholaris has good effects on mice with chronic bronchitis by enhancing the vitality of antioxidant enzymes, preventing lipid peroxidation, removing oxygen free radicals on the injury body, improving immune function and reducing airway inflammation.
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NSTL
万方数据
维普
