摘要
目的:研究轻度认知功能损害(mild cognitive impairment,MCI)脑内代谢变化及其与认知功能间的关系,寻求诊断MCI之客观指标,并探讨其对防治老年性痴呆(Alzheimet's disease,AD)之重要意义.方法:选择20例MCI患者,按照1:1配对,挑选20例健康志愿者作为对照组,利用氢质子磁共振波谱(1 H-magnetic resonance spectroscopy,1H-MRS)的方法,分别检测额叶、颞叶海马区域NAA,ml及Cho等代谢产物波峰的峰高,并以Cr峰高作为标准,计算各代谢产物与其比值,比较两组间的差别;同时,对MCI组的MMSE评分和NAA/Cr,ml/Cr及Cho/Cr进行相关分析.结果:MCI组患者脑内额叶和颞叶海马区域NAA/Cr较正常对照组显著下降,而ml/Cr和Cho/Cr与对照组间无显著差异.MCI组MMSE评分与额叶和海马区域NAA/Cr间均呈正相关关系,与nd/Cr及Cho/Cr间均无显著相关关系.结论:利用1H-MRS可以检测MCI患者脑内代谢变化,为MCI之诊断提供客观指标,且NAA/Cr变化可作为认知损害程度的客观指标,对AD早期防治具有重要意义.
Abstract
AIM: To study the metabolite changes in brain of patients with mild cognitive impairment (MCI) and its relationship with cognitive ability of the patients, to find an objective index for the diagnosis of MCI and to explore its significance in the prevention and treatment of Alzheimer' s disease ( AD). METHODS: According to 1:1 match principle, 20 patients with MCI and 20 healthy volunteers were selected and their metabolite changes of NAA, ml and Cho in frontal lobe and hippocampus of temporal lobe were detected with 1 H-magneric resonance spectros-copy (1H-MRS) and were compared between the two groups. Correlation coefficients between MMSE scores and NAA/Cr, mI/ Cr and Cho/Cr were calculated in MCI group. RESULTS: Compared with that of the control group, NAA/Cr in frontal lobe and hippocampus of the MCI patients reduced significantly. However, there were no significant differences in ml/Cr and Cho/Cr between the two groups. There was a significant positive correlation between MMSE scores and NAA/Cr and no significant correlation between MMSE scores and ml/Cr and Cho/Cr in MCI group. CONCLUSION: 1H-MRS can be used to examine the metabolite changes in brain of MCI patients, which provides an objective index for the diagnosis of MCI. Changes of NAA/Cr can be employed as an objective index for the degree of cognitive impairment, which is of great significance in the early prevention and treatment of AD.
基金项目
河南省医学科技创新人才工程项目(200515871)
NETL
NSTL
维普
万方数据