Changes of 1H-Magnetic resonance spectroscopy in patients with mild cognitive impairment and its signifi cance
AIM: To study the metabolite changes in brain of patients with mild cognitive impairment (MCI) and its relationship with cognitive ability of the patients, to find an objective index for the diagnosis of MCI and to explore its significance in the prevention and treatment of Alzheimer' s disease ( AD). METHODS: According to 1:1 match principle, 20 patients with MCI and 20 healthy volunteers were selected and their metabolite changes of NAA, ml and Cho in frontal lobe and hippocampus of temporal lobe were detected with 1 H-magneric resonance spectros-copy (1H-MRS) and were compared between the two groups. Correlation coefficients between MMSE scores and NAA/Cr, mI/ Cr and Cho/Cr were calculated in MCI group. RESULTS: Compared with that of the control group, NAA/Cr in frontal lobe and hippocampus of the MCI patients reduced significantly. However, there were no significant differences in ml/Cr and Cho/Cr between the two groups. There was a significant positive correlation between MMSE scores and NAA/Cr and no significant correlation between MMSE scores and ml/Cr and Cho/Cr in MCI group. CONCLUSION: 1H-MRS can be used to examine the metabolite changes in brain of MCI patients, which provides an objective index for the diagnosis of MCI. Changes of NAA/Cr can be employed as an objective index for the degree of cognitive impairment, which is of great significance in the early prevention and treatment of AD.
NETL
NSTL
万方数据
维普
