Study on differential efficacy of ser um chromatography of Carthamus tinctoriu L
AIM: To investigate the effective constituents of Carthamus tinctoriu L in rats using differential efficacy of serum chromatography. METHODS: High-performance liquid chroma-togmphy(HPLC) fingerprint was employed to compare the peaks of Carthamus tinctoriu L extract, blank serum, drug-containing serum at maximum efficacy time and drug-containing serum at minimum efficacy time. The chemical componential foundation of Carthamus tinctoriu L efficacy in blood stasis rats was determined. RESULTS: Twenty-eight compounds were detected after intragas-tric administration of Carthamus tinctoriu L extract, 20 of which were the original compounds containing in Carthamus tinctoriu L extract and 8 were metabolites. CONCLUSION: The 28 compounds under study are the possible effective constituents and further study may add to our understanding of the pharmacology and active mechanism of Carthamus tinctoriu L.
carthamus tinctoriusdifferential efficacy of serum chromatographychromatographyhigh pressure liquidfingerprint
NETL
NSTL
万方数据
维普
