Early diagnostic value of olfactory function measurement combined with MRI olfactory bulb volume measurement to Alzheimer's disease
AIM:To study the early diagnostic value of olfactory function measurement combined with MRI olfactory bulb volume measurement to Alzheimer's disease (AD). METHODS: Olfactory function measurement with picture-based odor identification test was conducted in 21 patients with AD and 21 healthy elderly subjects as control. Olfactory bulb volume and hippocampal volume in the two groups were measured with MRI. RESULTS: Olfactory function was significantly impaired in AD group compared with that in healthy control group(P < 0.05). The total scores of mini-mental state examination (MMSE) in AD group were negatively correlated with the olfactory detectability threshold and olfactory identification threshold(r= -0.50,r= -0.54,P<0.01). The hippocampal volume in AD group was significantly atrophic compared with that in controls(P<0.01) and a positive correlation in AD group was found between hippocampal volume and MMSE scores (r = 0.45,P < 0.05 ). The olfactory bulb volume significantly shrunk compared with that in control(P<0.01). In AD group,olfactory bulb volume was positively correlated with hippocampal volume and MMSE scores(r = 0. 72,P <0. 01;r =0. 50,P < 0.05),but negatively with olfactory detectability threshold and olfactory identification threshold (r = -0. 63,r = -0. 54,P < 0.05). CONCLUSION: Olfactory function measurement combined with MRI olfactory bulb volume measurement are of high early diagnostic value to Alzheimer' disease.
olfactory function measurementmagnetic resonance imagingolfactory bulb volumehippocampal volumealzheimer's disease
NETL
NSTL
万方数据
维普
