卵巢浆液性上皮癌中HLA-DR的表达结合血清CA125对评价肿瘤生物学恶性程度的意义
Significance of HLA-DR expression in serous epithelial ovarian carcinoma combined with serum CA125 in evaluating ovarian carcinoma malignancy behavior
主改侠 1刘莹 1张飞跃1
作者信息
- 1. 西安交通大学医学院第二附属医院妇产科,陕西,西安,710004
- 折叠
摘要
目的:研究HLA-DR在卵巢浆液性囊腺癌中的表达,结合患者术前血清CA125值,探讨两者对评价肿瘤生物学恶性程度的意义.方法:应用免疫组织化学方法检测40例卵巢浆液性囊腺癌、12例卵巢浆液性囊腺瘤、10例正常卵巢组织中HLA-DR的表达情况,收集40例卵巢癌患者术前血清CA125值.分析卵巢癌组织HLA-DR表达与卵巢癌临床病理特征的关系及和血清CA125的相关性.结果:卵巢癌组织中HLA-DR的阳性率为50.0%,显著高于其在正常卵巢组织及卵巢良性肿瘤中的表达;早期卵巢癌HLA.DR的阳性率显著高于晚期;高分化组HLA-DR的阳性率显著高于中、低分化组;HLA-DR的表达与卵巢癌患者术前血清CA125值呈显著负相关.结论:HLA-DR的表达与术前CA125的增高程度结合对判断卵巢癌生物行为学的恶性程度高低有重要意义.
Abstract
AIM: To evaluate the malignancy behavior of serous epithelial ovarian carcinoma with HLA-DR expression and serum CA125. METHODS: Forty cases of serous ovarian carcinoma,twelve cases of serous ovarian cystadenoma and ten cases of normal ovarian tissues were collected,and the level of pre-operational serum CA125 in ovarian carcinoma patients was also collected. HLA-DR was detected with immunohistochemistry in all cases. RESULTS: The positive rate of HLA-DR was 50. 0% in serous ovarian carcinoma tissues,obviously higher than that in both benign epithelial ovarian tumor and normal ovarian tissues. Significant difference was found in the positive rate of HLA-DR between early and late stages. The positive rate of HLA-DR was obviously higher in high differentiated group than that in medium and low differentiated group. HLA-DR expression had negative correlation with the pre-operational serum CA125 level. CONCLUSION: The expression of HLA-DR and high level of pre-operation serum CA125 can be markers to evaluate ovarian carcinoma malignancy behavior.
关键词
卵巢肿瘤/人白细胞DR抗原/血清CA125Key words
ovarian neoplasms/HLA-DR/serum CA125引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据