Correlations between protein expression of MTA1,HDAC1 and HIF-1α in lung cancers
AIM: To explore the correlations between protein expression of MTA1,HDAC1 and HIF-1α in lung cancers. METHODS: MTA1,HDAC1 and HIF-1α expressions were detected by immunohistochemistry in 59 lung cancer patients. The correlations between the expression of MTA1,HDAC1 and HIF-1α were analyzed. RESULTS: There was a positive association between the expression of MTA1 and HIF-1α (r =0. 418,P < 0.05). HIF-1α expression was correlated markedly with the MTA1/HDAC1 staining level. CONCLUSION: HIF-1α and MTA1/HDAC1 complex are of some significance in the development of human lung cancers. HIF-1α and HDAC1/MTA1 may be promising targets for novel therapeutic approaches to human lung cancers.
NETL
NSTL
万方数据
维普
