Evaluation of immunosuppressant mizoribine in preventing acute renal xenogeneic rejection
AIM: To investigate the efficacy and safety of mizoribine combined with cyclosporine ( CsA ) and prednisone in preventing acute renal xenogeneic rejection. METHODS: Sixty patients with kidney transplantation were randomly divided into treatment group (30 cases ) and control group (30 cases). The patients in treatment group were treated with mizoribine plus CsA and prednisone, while the patients in control group were treated with mycophenolate mofetil plus CsA and prednisone as usual. The acute rejection rate and time, the reduction rate of serum creatinine, the incidence of bone marrow suppression and the gastrointestinal tract reaction were observed and analyzed 6 months post-transplantation. RESULTS: The rejection rate and time in the treatment group was significantly lower but the average reduction rote of serum creatinine was sisnificantly higher compared with those in the control group (both, P<0.05). No significant difference was observed in the incidence of bone marrow suppression between the two groups (P>0.05), but the incidence of gastrointestinal reaction in the treatment group was significantly lower than that in the control group ( P < 0.05). CONCLUSION: Mizoribine with low toxicity effectively prevents acute renal xenogeneic rejection.
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NSTL
万方数据
维普
