Clinical analysis of uremic pruritus in patients maintaining hemodialysis
AIM: To investigate the prevalence, mechanism and prognostic significance of uremic pruritus (UP) in chronic hemodialysis patients. METHODS: Totally 238 aduh hemodialysis patients were inehded in this study and followed up for 3 years. The frequency and the intensity of UP were evaluated using visual analogue scale (VAS) in all the patients. The relationship between VAS scores and stable clinical or laboratory data was analyzed by multiple linear regression analysis. The relationship between UP and patient prognosis was also tested by Kaplan-meier analysis. RESULTS: One hundred and thirty-two patients were found having UP with a frequency of 55.5%. Of them, 53 cases (40.2%) had mild UP with a VAS score 1 -3, 59 cases (44.7%) had moderate UP with a VAS score 4 -6 and 20 cases ( 15. 1 % ) had severe UP with a VAS score 7 - 10. There were 31 patients (23.5%)with local UP and 101 patients (76.5%) with generalized UP. The analysis of multiple linear regression indicated that VAS score of UP was associated with the levels of serum iPTH, Ca × P product and hematocrit, but not with age, sex, duration of hexnndialysis, blood pressure, serum urea nitrogen, creatiniae, uric acid, calciam, phosphate, albumin, transferrin, Kt/V and C reactive protein (CRP). Kaplan-meier analysis also indicated that UP was not associated with the prognosis of patients. CONCLUSION: The intensity of UP in patients maintaining hemediulysis is associated with the levels of senun iPTH,Ca × P product and hematocrit, but not with age, sex, duration of hemodialysis, blood pressure, serum urea nitrogen, creatinine, uric acid, calcium, phosphate, albumin, tranferrin, Kt/V and CRP. UP is not a marker for poor prognosis.
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万方数据
维普
