Morphological characteristics of dendritic cells in human endometrioid adenocarcinoma
AIM: To investigate the morphological characteristics of dendritic cells (DCs) in human endometrioid adenocarcinoma. METHODS: Twenty cases of human normal endometrium in the postmenopause and 35 cases of endometrioid adenocarcinoma were collected and analyzed with immunobistochemistry and transmission eloctron microscopy. RESULTS: In comparison with that in control group, the morphological structure of DCs in human endometrioid adenocarcinoma showed the following diffennces: numerous DCs were small in volume end round in shape, but some were oval and multangular; the cytoplasmic processes were invisible and the nucleus became obviously small; round primary lysosome with high electron-densed granules and secondary lysosome with high or low electron-densed granules were seen frequently; DCs contained many rough endoplasmic reticulum (PER); the vacuoles with flocculent electron-deused granules were rare; high electron-deused contents in the granules were near one side and the other side was bright; the nucleus became markedly small in volume, nephroid or hoofed in shape; and the nucleus had little euchromatin and lots of heterochromatin under nuclear membrane. CONCLUSION: In comparison to the DCs of normal human endormetrium, the morphological differences of DC in endometrioid adenocarcinoma reflect the functional changes of the DCs in uptaking, processing and presenting antigen, which may lead to tumor immune escape.
NETL
NSTL
万方数据
维普
