Effects of rosiglitazone on cyclosporine A-related renal toxicity in rats
AIM: To investigate protective effect of rosiglitazone on cyclosporine A-related renal tissue renal interstitial fibrosis in rats. METHODS: Twenty-eight rats were randomly assigned to normal group (n=6,LSD),rosiglitazone [5 mg/( kg · d)] group (n=6,RGZ),cyclosporine A [15 mg/(kg · d)] group (n =8,CsA),and cyclosporine A [ 15 mg/( kg · d) ] and rosiglitazone [5 mg/(kg· d) ] group (n=8,RGZ + CsA). Immu-nohistochemistry and RT-PCR were used to investigate the pathological changes of the kidneys and the expression of CD68,Col Ⅳ,MMP-9 and TIMP-1 at the 2nd week and the 5th week in the rats in each group. RESULTS: In comparison with that in normal group,the expression of CD68,ColⅣ,MMP-9 and TIMP-1 in CsA group and CsA + RGZ group markedly increased ( P < 0.05). In comparison with that in CsA group,the expression of CD68,Col Ⅳ,MMP-9 and TIMP-1 significantly decreased in CsA + RGZ group (P<0.05). CONCLUSIOM: Rosiglitazone alleviates CsA-related renal interstitial fibrosis by decreasing the expression of CD68,ColⅣ,MMP-9 and TIMP-1.
cyclosporine ArosiglitazoneCD68ColⅣgelati-nase Btissue inhibitor of metalloproteinase-1renal interstitial fibrosis
NETL
NSTL
万方数据
维普
