Study on anti-chronic heart failure mechanisms of curcumin in rabbits
AIM:To investigate the therapeutic effect of curcumin on chronic heart failure rabbit model and its mechanisms. METHODS: Chronic heart failure model was produced by combined aortic regurgitation and coarctation of the abdominal aorta. Heart failure and sham-operation animals were further divided into curcumin group and placebo group. Ten weeks after operation,animals were examined by echocardiography to determine the effect of heart and the expression of cardiac myocytes sarco(endo) plasmic reticulum Ca2+-ATPase (SERCA2) protein was detected. RESULTS: Compared with those in sham-operation group,the left ventricle ( LV) diameter in heart failure group and curcumin-treated heart failure group enlarged,the ventricular wall thickened and the ejection fraction (EF) decreased. The expression of left ventricular SERCA2a protein decreased (P < 0.05). Compared with those in heart failure group,the LV diameter and wall in curcumin-treated heart failure group smaller and thinner,the ejection fraction (EF) was higher and the expression of SERCA2a protein were higher (P < 0.05 ). CONCLUSION: Curcumin improves the chronic heart failure rabbits model of heart function probably by increasing the expression of SERCA2.
NETL
NSTL
万方数据
维普
