Role of Ki67 in chemotheraphy by 5-FU in choriocarcinoma
AIM: To investigate the role of proliferating cell nuclear antigen( Ki67) in chemotheraphy by 5-FU in choriocarci-noma. METHODS:Choriocarcinoma cell JAR strain was used in this study and the inhibitory effects of chemotherapeutical drug 5-Fu (5-Fluorouracil) on JAR strain were assayed with MTT method. Expression of Ki67 was detected by reverse transcriptase PCR and Western blot. RESUTLS:5-FU inhibited the JAR cell growth in a dose and time dependent manner. Ki67 gene and protein decreased with the increase of 5-Fu. CONCLUSION: Ki67 is an important index in chemotheraphy by 5-FU and reflects the effect of chemotheraphy by 5-FU on choriocarcinoma.
NETL
NSTL
万方数据
维普
