Intervention of myocardial ischemiareperfusion arrhythmia and hemodynamics with lidocaine and verapamil
AIM: To investigate intervention of in vivo myocardial ischemia-reperfusion arrhythmia (RA) and hemodynamics with lidocaine and verapamil in SD rats. METHODS:SD rats were randomly divided into 4 groups:sham group,normal saline group (1.0 mL/kg),lidocaine group (10.0 mg/kg) and verapamil group (2.0 mg/kg). Middle segment of left coronary artery was occluded with silk suture for 20 rain and 2 min prior to reperfu-sion,normal saline,lidocaine or verapamil was administered iv. Suture was loosened to achieve reperfusion and left ventricular systolic/diastolic pressure (LVSP/LVDP),± dp/dt and ECG Ⅱ were continuously recorded. RESULTS: Comparison between 20 min after reperfusion and the onset of reperfusion revealed that the treatment intervened LVSP and ± dp/dt max statistically significant manner (P < 0. 05,P < 0. 05,P < 0. 01) but intervened LVDP in a statistically non-significant manner (P > 0.05). The treatment intervened the duration of QRS wave( P <0. 01),the mean of ST segment elevation ( MST) ( P < 0. 01),the heart rate(P<0.01) and the pressure-rate index(P <0.01) in a statistically significant manner. CONCLUSION: Intervention of RA with lidocaine and verapamil achieves substantial arrhythmic effects and decreases the myocardial consumption of oxygen. Lidocaine shortens DQRS significantly while verapamil significantly alleviates the ST segment elevation and slows the heat rate to decrease myocardial consumption of oxygen. However,both agents are liable to interfere with cardiac function and further result in an imbalance of hemodynamics.
NETL
NSTL
万方数据
维普
