Association between inhibitory KIR genotype assortment and acute rejection after kidney transplantation
AIM:To investigate the effect of inhibitory genotype assortment of killer immunoglobulin - like receptor ( KIR) on acute rejection ( AR) after cadaveric kidney transplantation. METHODS:Twenty-four randomized pairs of donors and recipients of kidney transplantation were investigated to define their KIR genotype assortments using PCR-SSP method. The effects of inhibitory KIR genotype assortment (AA) and non-inhibitory KIR genotype assortment ( BB,AB ) on AR were explored. RESULTS: Of the 24 pairs,AA KIR genotype assortment was found in 9 donors and 10 recipients,BB KIR genotype assortment was found in 3 donors and 4 recipients,and AB KIR genotype assortment was observed in 12 donors and 10 recipients. AR occurred in 10% (1/10) of the recipients with AA assortment and in 64.29% (9/14) of the recipients with BB & AB assortments,with significant difference between the two groups (P<0.05). AR occurred in 11.11% (1/9) of the donors with AA assortment and in 60% (9/15) of the donors with BB & AB assortments,with significant difference between the two groups ( P < 0. 05). AR occurred in 0% (0/4) of the donors/recipients with AA/AA match and in 50% (10/20) of the donors/recipients with non-AA/ AA match and no significant difference was found between them (P =0. 114). CONCLUSION: Recipients with AA KIR genotype assortment tend to have a lower incidence of AR. For recipients with BB & AB KIR genotype assortments,choice of a graft with AA KIR genotype assortment may reduce the incidence of AR. The underlying mechanism may be that AA KIR genotype assortment is characterized by inhibitory conducting signals.
NETL
NSTL
万方数据
维普
