抑制型KIR基因组合型与肾移植急性排斥反应的关系
Association between inhibitory KIR genotype assortment and acute rejection after kidney transplantation
付绍杰 1于立新 1罗敏 2肖露露 2王亦斌 1徐健 1杜传福 1邓文峰1
作者信息
- 1. 南方医科大学南方医院,器官移植科,广东,广州,510515
- 2. 南方医科大学南方医院,组织配型实验中心,广东,广州,510515
- 折叠
摘要
目的:探讨抑制型KIR基因组合型(AA类型)传导通路在尸体肾移植受者发生急性排斥反应(AR)中可能的作用.方法:应用PCR-SSP方法,检测24对肾移植供受者的KIR基因组合型,分析供受者AA类型和非抑制型KIR基因组合型(BB,AB类型)与肾移植术后AR的相关性.结果:24对供受者中AA类型供者9例,受者10例;BB类型供者3例,受者4例;AB类型供者12例,受者10例.AA类型受者AR发生率10%(1/10),BB和AB类型受者AR发生率64%(9/14)(P＜0.05).供者是AA类型受者AR发生率11%(1/9),供者是BB和AB类型受者AR发生率60%(9/15)(P＜0.05).供受者为AA/AA类型配型受者AR发生率为0%(0/4),而供受者不是AA/AA类型配型受者AR发生率为50%(10/20)(P=0.114).结论:从类型受者肾移植术后AR的发生率低,对BB或AB类型受者选择AA类型的供肾能够降低AR的发生率.从类型可能传导抑制信号为主.
Abstract
AIM:To investigate the effect of inhibitory genotype assortment of killer immunoglobulin - like receptor ( KIR) on acute rejection ( AR) after cadaveric kidney transplantation. METHODS:Twenty-four randomized pairs of donors and recipients of kidney transplantation were investigated to define their KIR genotype assortments using PCR-SSP method. The effects of inhibitory KIR genotype assortment (AA) and non-inhibitory KIR genotype assortment ( BB,AB ) on AR were explored. RESULTS: Of the 24 pairs,AA KIR genotype assortment was found in 9 donors and 10 recipients,BB KIR genotype assortment was found in 3 donors and 4 recipients,and AB KIR genotype assortment was observed in 12 donors and 10 recipients. AR occurred in 10% (1/10) of the recipients with AA assortment and in 64.29% (9/14) of the recipients with BB & AB assortments,with significant difference between the two groups (P<0.05). AR occurred in 11.11% (1/9) of the donors with AA assortment and in 60% (9/15) of the donors with BB & AB assortments,with significant difference between the two groups ( P < 0. 05). AR occurred in 0% (0/4) of the donors/recipients with AA/AA match and in 50% (10/20) of the donors/recipients with non-AA/ AA match and no significant difference was found between them (P =0. 114). CONCLUSION: Recipients with AA KIR genotype assortment tend to have a lower incidence of AR. For recipients with BB & AB KIR genotype assortments,choice of a graft with AA KIR genotype assortment may reduce the incidence of AR. The underlying mechanism may be that AA KIR genotype assortment is characterized by inhibitory conducting signals.
关键词
抑制型KIR组合/肾移植/移植物排斥Key words
inhibitory KIR/kidney transplantation/graft rejection引用本文复制引用
基金项目
广东省自然科学基金(81510515-1000047)
广东省科技计划项目(2008B030301140)
出版年
2009
NETL
NSTL
维普
万方数据