PTTG1和CycfinB1在结肠癌组织中的表达及临床意义
Expression of PTTG1 and CyclinB1 in human colon carcinoma and its clinical significance
赵钰 1卢启明2
作者信息
- 1. 兰州大学第一临床医学院,甘肃,兰州,730000
- 2. 甘肃省人民医院消化内科,甘肃,兰州,730000
- 折叠
摘要
目的:探讨结肠癌组织中垂体肿瘤转化基因1(PTTG1)和细胞周期蛋白B1(CyclinB1)的表达及临床意义.方法:应用免疫组化SP法检测65例结肠癌、30例结肠腺瘤和30例癌旁组织中PTTG1和CyclinB1的表达.结果:PTTG1和CyclinB1在癌旁组织中均无表达,在结肠腺瘤组织中表达率分别为13.3%和20.0%,在结肠癌组织中的表达率分别为72.3%和83.1%.PTTG1和CyclinB1的表达在癌旁组织和结肠腺瘤中与结肠癌中相比均有统计学意义(P＜0.05);PTTG1和CyclinB1的表达与肿瘤组织分化程度、淋巴结转移、远处转移及Dukes分期有关.结论:PTTG1和CyclinB1过表达可能参与结肠癌的发生发展,二者的过表达都可促进肿瘤细胞的浸润和转移.
Abstract
AIM: To investigate the expression of PTTG1 and CyclinBl in human colon carcinoma and its significance. METHODS: Immunohistochemical SP method was used to test the expressions of PTTG1 and CyelinB1 in 65 cases of human colon carcinoma,30 cases of human colon adenoma and 30 cases of human mucosa adjacent to carcinoma. RESULTS: No expression of PTTG1 and CyclinB1 was observed in mucosa adjacent to carcinoma. The positive expression rates of PTTG1 and CyclinB1 were respectively 13.3% and 20.0% in colon adenoma and were respectively 72. 3% and 82. 1% in colon carcinoma. Significant difference was found between PTTG1 and CyclinB1 expression of mucosa adjacent to carcinoma and colon adenoma and that in colon carcinoma (P<0.05). The expressions of the PTTG1 and CyclinB1 were related with histological differentiation,lymph node metastasis,distant metastasis and Dukes stage. CONCLUSION: The over-expression of PTTG1 and CyclinB1 may be involved in the progression and metastasis of colon carcinoma.
关键词
垂体肿瘤转化基因1/细胞周期蛋白B1/结肠肿瘤/免疫组织化学Key words
pituitary tumor transforming gene 1/cyclin B1/colonic neoplasms/immunohistochemistry引用本文复制引用
出版年
2009
NETL
NSTL
万方数据