Expression of human cervical cancer oncogene(HCCR)in colon cancer
AIM:To detect the expression of human cervical cancer oncogene (HCCR) in human colon cancer,to explore the relations between expression of HCCR with colon cancer and to investigate the role of HCCR in colon cancer. METHODS: The expression of HCCR was detected in 20 patients with normal colonical tissues,21 patients of colon adenoma tissues and 56 patients of colon carcinoma tissues by immunohistochemiscal SP staining method. RESULTS: No expression of HCCR was observed in normal colon tissue. The positive rate of HCCR expression was 48% in colon adenoma and 77% in carcinoma tissue. The expression of HCCR in colon adenoma tissues and in colon carcinoma tissues was significantly higher than that in normal colon tissues (χ2 = 13. 061,P <0. 05),with significant difference between colon adenoma and carcinoma tissue ( χ2= 6.056,P <0.05). The HCCR expression in carcinoma tissue was significantly correlated with the histological type (χ2 = 5. 714,P <0. 05),but not significantly with age,gender,site or size of tumor,histological grade,local lymph node involvement and Dukes stage ( P > 0. 05). CONCLUSION: HCCR may play an important role in the early occurrence of colon cancer. Though not as good as joint detection of CEA and CA19-9,HCCR is better than single detection of CEA or CA19-9 in the diagnosis of colon cancer.
NETL
NSTL
万方数据
维普
